PhD scholarship in Bacterial Pathogen Metabolism

Danmarks Tekniske Universitet (DTU)

Ph.d. & forskning

Frist 31. august 2017

A PhD scholarship is available in the Center for Hyperpolarization in Magnetic Resonance (HYPERMAG) at DTU Electrical Engineering, starting in fall 2017. HYPERMAG is a Center of Excellence founded by the Danish National Research Foundation.

We conduct research within the field of biomedical engineering with the aim of conducting real time functional imaging by tracking metabolic processes with isotope labelled tracers. The center specializes in a technology, hyperpolarization with dissolution dynamic nuclear polarization, that produce signal enhancement on NMR active nuclei with orders of magnitude. This large signal increase allows direct detection of metabolism in living objects from cell to man. We focus on developing new applications that exploit the ability of the signal enhanced tracers to observe transient states in metabolic networks.

The subject of the announced PhD project is metabolic research within bacterial pathogens and their hosts. The aim is to investigate metabolic crosstalk between intracellular pathogens and their host using the unique possibilities of hyperpolarized tracers. Little is known about this crosstalk and as a consequence also how external impacts such as drugs or prebiotics affects the interlinked metabolism of the pathogen and host cells in the gut epithelium.

Responsibilities and tasks
The PhD candidate will be working with interdisciplinary experimental research rooted in microbiology.

The project will include:

  • Cellular work with bacterial pathogens mainly shigella, listeria and salmonella.
  • Adaptation of a cellular infection model based on caco-2 cells used for drug screening.
  • Development of tracer experiments on infected gut epithelium tissue from mice.
  • Study of effects of drugs and prebiotics on the diseased metabolome.
  • Application of hyperpolarized NMR as main technique for investigating the disease metabolome as well as use and implementation of standard biochemical assays.

We seek an enthusiastic candidate with background in microbiology, biotechnology, systems biology, pharmacology or equivalent to carry out this interdisciplinary project. Track record in experimental work within microbiology is preferred. Good communication skills in English, both written and spoken, are required.

Candidates should have a MSc in engineering or a similar degree with an academic level equivalent to the MSc in engineering.

Approval and Enrolment
PhD scholarships are subject to academic approval, and the candidates will be enrolled in one of the general PhD programmes at DTU. For information about the general requirements for enrolment and the general planning of the scholarship studies, please see the DTU PhD Guide.

The assessment of the applicants will be made by Associate Professor Pernille Rose Jensen and Senior Researcher Mathilde Lerche. Final assessment will be on the basis of an interview.

You are more than welcome to contact us at email: .

We offer
We offer an interesting and challenging job in an international environment focusing on education, research, scientific advice and innovation, which contribute to enhancing the economy and improving social welfare. We strive for academic excellence, collegial respect and freedom tempered by responsibility. The Technical University of Denmark (DTU) is a leading technical university in Northern Europe and benchmarks with the best universities in the world.

Salary and appointment terms
The salary and appointment terms are consistent with the current rules for PhD students. The period of employment is 3 years.

Further information
Further information may be obtained from Pernille Rose Jensen, associate professor, phone: +45 4525 3688


You can read more about Center for Hyperpolarization in Magnetic Resonance on

Please submit your online application no later than 31 August 2017. Applications must be submitted as one pdf file containing all materials to be given consideration. To apply, please open the link "Apply online," fill in the online application form, and attach all your materials in English in one pdf file. The file must include:

  • A letter motivating the application (cover letter)
  • Curriculum vitae
  • Grade transcripts and BSc/MSc diploma
  • Excel sheet with translation of grades to the Danish grading system (see guidelines and excel spreadsheet here)

Candidates may apply prior to ob­tai­ning their master's degree, but cannot begin before having received it.

All qualified candidates irrespective of age, gender, race, disability, religion or ethnic background are encouraged to apply.

The Department of Electrical Engineering is the central department at the Technical University of Denmark in electrical, biomedical engineering and acoustic technology. It is our goal to ensure an engineering training and research, which matches that of other leading universities around the world. The department is organized into sections each covering important areas of electrical, biomedical engineering and acoustic technologies. Including PhD students we have a total of 275 staff members.DTU is a technical university providing internationally leading research, education, innovation and scientific advice. Our staff of 5,800 advance science and technology to create innovative solutions that meet the demands of society; and our 10,600 students are being educated to address the technological challenges of the future. DTU is an independent academic university collaborating globally with business, industry, government, and public agencies.

Ansøgningsfrist d. 31.08.2017

Ph.d. & forskning
Elektro & Telekommunikation
Fødevarer & Veterinær
Kemi, Biotek & Materialer
Medicinal & Sundhed
Teknik & Teknologi
Forskning & Udvikling
Fejlmeld opslaget

Opslag oprettet d. 17.07.2017, sidst opdateret d. 17.07.2017

Danmarks Tekniske Universitet (DTU) - hurtig overblik

Leveret af

Anker Engelunds Vej 1 101 A
2800 Kgs. Lyngby

Forskning & Uddannelse

Vi lever af at sælge know-how, og vi bliver stadig bedre til det. Det sørger lærerne for.

Logo: Danmarks Tekniske Universitet (DTU)

Hvilke jobtyper og arbejdsområder udbyder vi normalt?

Nyeste tweets
Henter tweets...
Facebook feed
Henter facebook feed...

Få mere info omkring vores virksomhed på vores egne websider:

Danmarks Tekniske Universitet (DTU) i Google

Er der andre informationer om os, som du burde vide? Se, hvad en Google-søgning siger.
Vi bruger cookies til statistik, sociale medier og brugeroplevelse. Ved at bruge sitet accepterer du vores privatlivspolitik. (luk)