PhD position in Imaging Systems for Simultaneous Two- and Three-Photon Microscopy

Danmarks Tekniske Universitet (DTU)

Ph.d. project
Abroad (other)
Greater Copenhagen

Frist 1. oktober 2017

The Department of Photonics Engineering at the Technical University of Denmark (DTU) is seeking a candidate for a PhD position on optical imaging systems for simultaneous two- and three-photon microscopy with novel light sources.

The PhD student will join the Diode Lasers and LED Systems group at the Department of Photonics Engineering (DTU Fotonik) consisting of 25 employees, including several PhD students and postdocs. Within the group, we are working on the advancement of optical imaging technologies in a clinical environment. Currently we have research projects on multimodal imaging combining OCT, OCM and Two-Photon Microscopy, fibre delivery of ultrashort pulses, as well as investigation of biomarkers relevant for cancer diagnosis using optical imaging.

Description of PhD project
Two of the most important performance parameters in in vivo fluorescence microscopy are the imaging depth and the signal to noise ratio (SNR). Three-photon fluorescence microscopy using near-infrared light (1200 – 1500 nm) for excitation offers great promise to improve both parameters compared to single-photon excited fluorescence microscopy. The added benefit of this excitation scheme is the simultaneous presence of second harmonic (SH), third harmonic (TH), two-photon fluorescence, and three-photon fluorescence signals from different fluorophores and structures. However, a suitable ultrafast pulsed laser for such a microscopy system is currently not commercially available.

In this project, the PhD student will help us expand our research group’s imaging capabilities into the three-photon regime by first realizing two approaches to a laser source for such a system: One based on adiabatic soliton compression in long Raman fibres and one based on soliton fission in photonic crystal fibres. Next, the student will design and assemble a microscopy system that can accommodate the involved wavelengths for multiphoton imaging. Finally, he or she will demonstrate its enhanced functional imaging capabilities using biological samples. This system will be used for functional imaging of zebrafish and neuronal function in mice brain. Put into a broader perspective, the imaging system could help better understand drug efficacy and diseases such as Alzheimer’s, dementia etc.

During the project, the PhD student will collaborate with NKT Photonics (soliton fission schemes) and the group of Roy Taylor at Imperial College London (Raman fibre laser schemes) for the pulsed laser development. Furthermore, he or she will also interact with other PhD students in the two European Projects “MIB” and “FBI”. MIB provides close collaboration with Gentofte Hospital, while FBI consists of early stage researchers (PhD students) strengthening European collaboration between industry and academia. These projects include partners in Denmark, The Netherlands, Germany, Austria, Lithuania and Switzerland.

Qualifications
The candidate should have a master's degree in applied physics, biophotonics, photonics engineering or a similar degree with an academic level equivalent to the master's degree. A solid background in optics and photonics is an asset, and knowledge of microscopy is an advantage. We expect the candidate to have good laboratory skills in the above areas. Good communication skills in written and spoken English is a must.

Approval and Enrolment
The scholarship for the PhD degree is subject to academic approval, and only candidates with an above the average marks are accepted in the program. We recommend the applicants to contact the supervisors in advance to assess the suitability of the application.

Candidates will be enrolled in one of the general degree programs of DTU. For information about the general requirements for enrolment and the general planning of the scholarship studies, please see the DTU PhD Guide. You can read more about Department of Photonics Engineering on www.fotonik.dtu.dk.

We offer
We offer an interesting and challenging job in an international environment focusing on education, research, scientific advice and innovation, which contribute to enhancing the economy and improving social welfare. We strive for academic excellence, collegial respect and freedom tempered by responsibility. The Technical University of Denmark (DTU) is a leading technical university in northern Europe and benchmarks with the best universities in the world.

Salary and appointment terms
The salary and appointment terms are consistent with the current Danish rules for Ph.D. degree researchers. The period of employment is 3 years. Part of the project may be carried out at one of our partner’s laboratory abroad. Starting date is spring 2018.

Assessment
The assessment of the applicants will be made by: Peter E. Andersen, Anders K. Hansen and Dominik Marti.

Further information
Further information may be obtained from Dr. Peter E. Andersen, tel. +45 46774555

, email , Dr. Anders K. Hansen, tel. +45 46774586,

email , or Dr. Dominik Marti, tel. +45 46774568

, email .

Application
Please submit your application as soon as possible and no later than 1 October 2017. Applications must be submitted as one pdf file containing all materials to be given consideration. To apply, please open the link "Apply online," fill in the online application form, and attach all your materials in English in one pdf file. The file must include:

  • A letter motivating the application (cover letter)
  • Curriculum vitae
  • Grade transcripts and BSc/MSc diploma
  • Excel sheet with translation of grades to the Danish grading system (see guidelines and excel spreadsheet here)

Candidates may apply prior to ob­tai­ning their MSc degree, but cannot begin before having received it.

All interested candidates irrespective of age, gender, race, disability, religion or ethnic background are encouraged to apply.

DTU is a technical university providing internationally leading research, education, innovation and scientific advice. Our staff of 5,800 advance science and technology to create innovative solutions that meet the demands of society; and our 10,600 students are being educated to address the technological challenges of the future. DTU is an independent academic university collaborating globally with business, industry, government, and public agencies.


Application deadline 01 October 2017

Ph.d. project
Abroad (other)
Greater Copenhagen
Chemistry, Biotech & Material Sciences
Machine & Technical Design
Math, Physics & Nanotech
Medicine & Health
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Ad created on 01 September 2017, last update on 01 September 2017




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